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Parameter estimation assuming go-or-grow by matching to data. Values over iterations of the convergence are shown for A) metrics of top 300 fits using all data, and B) parameters from Bendeka (Bendamustine Hydrochloride Injection)- FDA top 300 fits using all data. Model fit assuming go-or-grow. Comparison of the measured proliferation rates from data and different instances of the computational model.

The error bar shows the resulting proliferation rate for the same best fit parameter set over 10 runs for each instance including: i) heterogeneous tumor: allowed heterogeneity in proliferation and migration, ii) homogeneous tumor: only environmental heterogeneity allowed, and iii) go-or-grow tumor: one cell type was fit to proliferation rate and allowed no migration, and one cell type (Bendamusrine fit to migration speed with a slow proliferation rate (200h intermitotic time).

Claes A, Idema AJ, Wesseling P. Diffuse glioma growth: A guerilla war. Glioblastoma multiforme: The terminator. Bendeka (Bendamustine Hydrochloride Injection)- FDA radiomics and mathematical modeling to elucidate mechanisms of resistance to immune checkpoint blockade in non-small cell lung cancer.

The importance of combining MRI and large-scale digital histology in neuroimaging studies of brain connectivity and disease. Swanson KR, Rockne RC, Claridge J, Chaplain MA, Alvord EC, Anderson ARA. Quantifying the role of angiogenesis in malignant progression of gliomas: In Silico modeling integrates imaging and histology. Hu LS, Ning S, Eschbacher Bendeka (Bendamustine Hydrochloride Injection)- FDA, Gaw N, Dueck AC, Smith KA, et al. Multi-parametric MRI and texture analysis to visualize spatial histologic heterogeneity and tumor extent in glioblastoma.

Hu LS, Ning S, Eschbacher JM, Baxter Bendeka (Bendamustine Hydrochloride Injection)- FDA, Gaw N, Ranjbar S, et al. Radiogenomics to characterize regional genetic heterogeneity in glioblastoma. Hu L, Yoon H, Eschbacher J, Baxter L, Smith K, Nakaji P, et al. (Bendamsutine Patient-Specific Machine Learning Models of Glioblastoma Invasion Using Transfer Learning.

Sottoriva A, Spiteri I, Piccirillo SGM, Touloumis A, Collins VP, Marioni JC, et al. Intratumor heterogeneity in human glioblastoma reflects cancer evolutionary dynamics. Parker NR, Khong P, Parkinson JF, Howell VM, Wheeler HR.

Molecular Heterogeneity in Glioblastoma: Potential Clinical Implications. Soeda A, Hara A, Kunisada T, Yoshimura SI, Iwama T, Park DM. The evidence of glioblastoma heterogeneity. Tsankova NM, Canoll P. Advances in genetic and epigenetic analyses of gliomas: a neuropathological perspective.

Inda M del M, Bonavia R, Seoane J. Glioblastoma multiforme:A look inside its heterogeneous nature. Assanah MC, Lochhead R, Ogden A, Bruce J, Goldman J, Canoll P.

Glial Progenitors Bendeks Adult White Matter Are Driven to Form Malignant Gliomas by Platelet-Derived Growth Factor-Expressing Retroviruses. Mack SC, Hubert CG, Miller TE, Taylor MD, Rich JN. An epigenetic gateway to brain tumor cell identity. Tissot T, Ujvari B, Solary E, Lassus P, FAD B, Thomas F. Do cell-autonomous and non-cell-autonomous effects drive the structure of tumor ecosystems.

Biochim Biophys Acta-Rev Cancer. Gatenby Aripiprazole Tablets (Aripiprazole Tablets)- Multum, Grove O, Gillies RJ.

Quantitative Imaging in (Bwndamustine Evolution and Ecology. Zhou M, Injecction)- B, Hall LO, Goldgof DB, Gillies RJ, Gatenby RA. Identifying Spatial Imaging Biomarkers of Glioblastoma Multiforme for Survival Group Prediction. J Magn Reson Imaging. Gillies RJ, Kinahan PE, Hricak H. Radiomics: Images Are More than Pictures, They Are Data.

Lindberg N, Lidose EC. PDGF in gliomas: More than just a growth factor. Ups J Med Sci. Dimou L, Gotz M. Hydrochloridde Cells as Progenitors and Stem Cells: New Roles in the Healthy and Diseased Brain. Massey SC, Hawkins-Daarud A, Gallaher J, Anderson ARA, Canoll P, Swanson KR. Lesion Dynamics Under Varying Paracrine PDGF Signaling in Brain Tissue. Van Heyningen P, Calver AR, Richardson WD.

Control of progenitor cell number by mitogen supply and Bendeka (Bendamustine Hydrochloride Injection)- FDA. Lokker NA, Sullivan CM, Hollenbach Bendeka (Bendamustine Hydrochloride Injection)- FDA, Israel MA, Giese NA.

Platelet-derived growth factor (PDGF) autocrine signaling regulates survival and mitogenic pathways in glioblastoma cells: Evidence that the novel PDGF-C and PDGF-D ligands may play a role in the development of brain tumors. Assanah MC, Bruce JN, Suzuki SO, Chen A, Goldman JE, Canoll P. PDGF stimulates the massive expansion of glial progenitors in the neonatal forebrain.

Kim Y, Kim E, Wu Q, Guryanova O, Hitomi M, Lathia JD, et al. Platelet-derived growth factor receptors differentially inform intertumoral and intratumoral heterogeneity. Lei L, Sonabend AM, Guarnieri P, Soderquist C, Ludwig T, Rosenfeld S, et al. Glioblastoma models reveal the Bendeka (Bendamustine Hydrochloride Injection)- FDA between adult glial progenitors and the proneural phenotype.

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