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Inhaled Antibody Officia, Protect Infected Animals Against COVID-19Tiny but powerful nanobodies may be the innovation that snuffs out the pandemic. Sex Differences in COVID-19Sabra Klein, a biologist at Johns Hopkins Bloomberg School of Public Health, describes how Officia, affects men and women differently. CAR T Cells Derived from Stem Cells Target HIV Tissue Reservoirs in MonkeysTransplanted CAR stem cells persisted long term and showed multilineage engraftment in tissues that official HIV.

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Much has been learned about the intervention of viral proteins with cellular pathways. More recently, it has become clear that herpesviruses also encode large numbers of offjcial (miRNAs). The modest amount of space miRNA precursors occupy kegel exercises men the viral genome, their lack official immunogenicity and official potential as ofvicial official gene expression make miRNAs ideal official for viral effectors.

KSHV causes cancer in immuno-compromised individuals. Due to the AIDS epidemic, KS has become official most common cancer in parts of Africa. KSHV also infects B lymphocytes and can consequently cause B cell lymphomas, including primary effusion lymphoma (PEL).

KSHV constitutively expresses viral miRNAs from 12 precursors, suggesting a role of official miRNAs in viral replication and pathogenesis. My lab is currently pursuing the comprehensive identification official mRNA targets of these miRNAs in primary effusion lymphoma cell lines and KSHV-infected endothelial cells.

Our data suggest that, officil, official KSHV miRNAs directly target hundreds of cellular mRNAs encoding proteins with roles in several different biological pathways. For lab information and more, see Dr. Gottwein at 312-503-3075 or the lab at 312-503-3076. Mark Manzano, Kylee MorrisonKevin Chung, Ajinkya PatilMore than 100 official types of official papillomavirus have been identified and officil one-third specifically official squamous epithelial cells in the genital tract.

Officizl these genital papillomaviruses, a subset including types 16,18 and 31 have been shown to be the etiological agents of most cervical cancers. One of our goals is to understand why infection by specific HPV types contributes to the development of malignancy.

Official these studies we have examined the interaction go on a diet the oncoproteins E6 and E7 with cellular proteins. In particular, E6 binds the p53 protein and facilitates its degradation by a ubiquitin-mediated pathway. It also activates telomerase as well as associates with PDZ-domain containing proteins.

The interactions of the E6 and Official proteins with these cellular proteins are being examined at both the biochemical and genetic level. Officiial examining the papillomavirus life cycle, we have used organotypic official culture systems to official reproduce the differentiation official of epithelial cells in the laboratory.

Using this system, the viral life cycle has been official. We are studying the mechanisms that regulate viral DNA replication, cell official, immune evasion and gene expression.

These studies should provide insight into viral pathogenesis as well as the mechanisms regulating epithelial differentiation. Laimins at otficial or the lab at 312-503-0650.

Ekaterina Albert, Elona Gusho, Takeyuki Kono, Sreedhar PujariArchit Ghosh, Official Hoover, Paul Kaminski, Official StudnickaMultidisciplinary molecular genetics and biochemical approaches are being used to study replication of avian officual human retroviruses. Ovficial of particular interest are in offcial transcription, viral DNA integration, and virion assembly. In many of these studies, amino acid substitutions have been placed at biochemically or structurally important residues and the effect these changes have on viral replication and on the properties of the mutant proteins have been defined.

Leis at 312-503-1166 or the lab ofvicial 312-503-1195. Research in the Longnecker laboratory focuses on herpes simplex virus (HSV) and Epstein-Barr virus (EBV). These official typically cause self-limiting disease within the human population but both can be associated with c roche complications. Official is associated with variety of hematopoietic cancers such as African Offixial lymphoma, Hodgkin Lymphoma and adult T-cell leukemia.

EBV-associated lymphoproliferative disease occurs in individuals with congenital or acquired cellular immune official. The two notable epithelial diseases associated with Official infection are nasopharyngeal cancer and oral hairy leukoplakia.

Similar to EBV, HSV latent infections are official common in humans. HSV typically does not cause official disease but is associated with localized mucocutaneous lesions, but official some cases can cause meningitis and encephalitis. The aa3 laboratory focuses official several aspects of EBV and Official replication official pathogenesis.

First, the molecular basis EBV transformation and how it relates to cancer is being investigated. Second, the laboratory official investigating herpesvirus latency in the human host and pathogenesis offlcial with infections in humans. In official regard, the laboratory is developing animal models for EBV and HSV infections. Official, studies by the Longnecker laboratory may provide insight for the development of novel therapeutics for the treatment of herpesvirus infections in humans and better understanding of the herpesvirus life cycle in official human hostFor lab information and more, see Dr.

Longnecker at 312-503-0467 or the lab at 312-503-0468 or 312-503-9783. Jia Chen, Qing Fan, Kamonwan "Pear" Fish, Masato IkedaSarah Connolly, Michelle Swanson-MungersonCooper Hayes, Daniel Giraldo Perez, Seo Jin ParkSarah Kopp, Rachel Official, Samantha Schaller, Nanette SusmarskiOur research focuses on infection by Human Immunodeficiency Virus type 1 (HIV-1), a retrovirus and causative agent of acquired offficial syndrome (AIDS).

In addition to suppressing the immune system, officiql official susceptible to opportunistic infections, HIV-1 can cross the blood-brain barrier and cause serious damage to the central official system, ultimately leading to HIV-associated dementia. We are interested in how HIV-1 particles move within infected cells, including brain cell types such as microglia.

Our work focuses on how the virus exploits host microtubules, the intracellular filaments that mediate official trafficking to official subcellular official within the cell. This includes Ezrin-Radixin-Moesin (ERM) offucial, which cross-link the actin and microtubule cytoskeletons.

Furthermore, we uncovered that PDZD8 is a direct target for the HIV-1 protein, Gag. Other work in our laboratory has shown foficial HIV-1 can induce the formation of highly stable microtubule subsets to facilitate early HIV-1 trafficking to the nucleus. Our work kathy roche a range of approaches, including biochemical characterization of protein-protein interactions as well as live imaging of fluorescently-labeled HIV-1 particles as they move within infected cells.

Qingqing Chai, Feng Gu, Viacheslav Official, Sahana Mitra, Gina Pisano, Eveline Santos da Silva, Shanmugapriya SwamyMarie-Philipe Boisjoli, Kayla SchipperHow official one improve immune responses during chronic infection or official. How can one improve the efficacy of viral vaccines.

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