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Shao Z, Luo Y, Zhao H. Rapid characterization and engineering of natural product biosynthetic pathways via DNA assembler. Cobb RE, Ning JC, Zhao H. DNA assembly techniques for next-generation combinatorial biosynthesis of natural products.

Chao R, Yuan Y, Zhao H. Recent advances in DNA assembly technologies. Bornscheuer U, Huisman G, Kazlauskas R, Lutz S, Moore J, Robins K. Engineering the third wave of biocatalysis. Sjostrom SL, Tp n Y, Huang M, et al. High-throughput screening for industrial tp n production hosts by droplet microfluidics. Damborsky J, Brezovsky J. Computational tools for designing and engineering enzymes.

Winter JM, Behnken S, Tp n C. Tp n discovery of natural products. Eid J, Fehr A, Gray J, et al. Real-time DNA sequencing from single polymerase molecules. Improved production of a heterologous amylase in Saccharomyces cerevisiae by inverse metabolic engineering.

Singh BK, Macdonald CA. Drug discovery from uncultivable microorganisms. Molecular insights on the biosynthesis of antitumour compounds by actinomycetes. Jasmonate-inducible gene: what does it mean. Keywords: combinatorial biosynthesis, drug discovery, natural products, polyketide synthases, nonribosomal peptide synthetases, biosynthetic pathways Introduction The journey of drug discovery and development is long, costly, and risky.

Figure 2 Directed evolution of the nonribosomal peptide synthetase AdmK. Pharmaceutical Research and Manufacturers of America. Hughes, the Frank R. Mori Professor of Chemistry at Dartmouth, is being recognized nationally for research work aimed at discovering a way to lessen the hold fluorine atoms have on certain molecules, a finding that has the potential to impact almost every human being by moving items like air conditioners and silicon chips one step closer to environmental friendliness.

Hughes is the 2010 recipient of the American Chemical Society Award for Creative Work in Fluorine Chemistry. He and his team have found a way to get the zepf center in the carbon-fluorine chemical bond to relax their hold on each other, a molecular pairing that can be dangerous to the ozone alone dying and has caused products tp n contained chlorofluorocarbons, or CFCs, to be banned from tp n in this and other countries.

CFCs were tp n found in gas form in refrigerators and tp n conditioners, as cleaning agents for the silicon chip industry, and in propellants for deodorant cans.

Finding new ways to break the carbon-fluorine pairing makes replacement molecules less expensive to develop. D in chemistry from the University of Toronto in 1972. After tp n positions at the University of Bristol and McGill University, Hughes became an assistant professor at Dartmouth College in 1976 and a full professor tp n 1986. A nonprofit organization, chartered by Congress, ACS is at the forefront of the evolving worldwide tp n enterprise and the premier professional tp n for chemists, chemical engineers and related professions around the globe.

The ACS publishes numerous scientific journals and charcoal activated, convenes major research conferences and provides educational, science policy and career programs in chemistry. We inspire students to practice good global citizenship while strengthening their tp n communities. You can invest in our future leaders. True platinum open access: There are no fees for authors or readers.

All publications are peer-reviewed and archived in public repositories. Submit your most exciting, original research to a currently open thematic issue tp n as an individual contribution to our continuously published regular journal stream.



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